chlorine dioxide products 2.jpg


How can you apply chlorine dioxide in air against COVID-19 and other diseases?

The COVID-19 pandemic has created intense need for contagion control in all types of conditions throughout the world. Chlorine dioxide presents what might be one of the most rapid, cost-effective and practical solutions for reducing coronavirus germs being transmitted among people.
Chlorine dioxide has demonstrated potent effectiveness against SARS-CoV-2 coronavirus
  • Laboratory testing showed the formulation of one liquid product with 24 ppmW of ClO2 destroyed more than 99.9% of SARS-CoV-19 in 10 seconds, and one mouth rinse containing sodium chlorite (stabilized chlorine dioxide) destroyed up to 98.4% in 30 seconds in simulated saliva. Study 10 , Study 12
On the US EPA's List N, 10 Chlorine Dioxide and ?? Sodium Chlorite products are listed as effective disinfectants to use against COVID-19.
However, one single method cannot work for applying all chlorine dioxide products nor for all situations.
  • Different chlorine dioxide products' formulations vary significantly in the ways they are mixed, concentration levels, and time until full strength is reached and then diminished.
  • Many tools can be chosen for releasing chlorine dioxide into air, but they need accurate adaptations for use.
  • The size of an area and its environmental conditions also strongly influence the strength of chlorine dioxide needed for protection of the space.
Chlorine dioxide products are not widely marketed for use in air. Chlorine dioxide products with instructions customized for airborne use are very limited.
Because the urgency of the COVID-19 pandemic presents intense need for contagion control, and using chlorine dioxide in air can radically increase the safety levels of both air and surfaces it lands on,  pivotal 
Below are 7 steps to follow to help you determine how to use chlorine dioxide for your speci
This website outlines steps that can be followed to help determine accurate amounts for your specific application, using a variety of tools in a variety of environments.
Answers to the following 5 questions can provide guidance for determining how much chlorine dioxide to use in your specific situation.

Question 1:

What air concentration of chlorine dioxide is effective at destroying various viruses and bacteria?

  • Level tested to protect against airborne flu virus:
    0.03 ppmV was found to significantly protect against flu in one study with mice.

  • More research and applications using chlorine dioxide in air to fight contagion among people:
    Studies and tools using chlorine dioxide in air to fight viruses around people.

Question 2:

What concentration of chlorine dioxide in air is safe for people to breathe?

  • "Permissible Exposure Limit Time-Weighted Average"
    0.1 ppmV air concentration approved by OSHA to be harmless to breathe 8 hours/day every workday for 45 years.

  • "Permissible Exposure Limit Short Term"
    0.3 ppmV is the NIOSH recommended maximum for any 15-minute time period.

Question 3:

What tools can you use to apply chlorine dioxide to air?

  • Options include: 

    • Portable, whole-room ultrasonic humidifier

    • Personal-size ultrasonic humidifier

    • Small air pump and tube beside any open container

    • "Fogger" machine

Question 4:

Which chlorine dioxide product formulation will be appropriate?

  • The US OSHA has approved chlorine dioxide to be continually present in any workplace (up to 0.1 ppmV). Several types of chlorine dioxide formulations are able to be applied safely and effectively to air. However, few have  chlorine dioxide products are labelled for applying to air around people. If you purchase one, use the instructions on the label


Question 5:

How many milligrams of "free" chlorine dioxide are needed in your air space?

  • Use our helpful "Chlorine Dioxide In Air" Calculator below.

Question 6:

What adjustments are needed for your specific environment?

  • Simply releasing the target amount of chlorine dioxide will not achieve the desired concentration in your room space. Various environmental conditions can require adjustments to be made.


Conditions that can affect chlorine dioxide use in air include:

  • Altitude

  • Temperature

  • Lighting conditions

  • Air flow from doors and windows

  • Air flow from HVAC systems

  • Humidity (including equilibrium of gas in air vs. within liquid aerosols)

  • Surface types in room

  • Accumulation over time


More information on these will be added on this site soon.

Question 7:

How much of the chlorine dioxide product do you need to use in the application tool you have chosen, and how often?

  • For medium size ultrasonic humidifiers, use our calculator below.

  • We are developing calculators for using other methods.


Note: Calculators have been updated and are currently undergoing verification.

Calculate the amount of
Chlorine Dioxide needed for a specific concentration in air

Using Chlorine Dioxide in an Ultrasonic Humidifier

Technical Note

Chlorine dioxide's molecular weight is 67.45. For the calculators above, a conversion factor of 2.8 was used for chlorine dioxide in converting from 1 ppmV (parts-per-million volume/volume) to 2.8 mg/m3 in air.

* See NIOSH Occupational Exposure Banding e-Tool , and Parts Per Million (ppm) Converter for Gases .